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王 辉 博士 二级教授

第六届中国免疫学会常务理事,中国免疫学会科普与教育工作委员会副主任委员。

中国免疫学杂志、细胞与分子免疫学杂志、国际免疫学杂志编委、新乡医学院学报主编。

河南省分子诊断与医学检验技术协同创新中心 常务副主任

新乡医学院免疫学研究中心 主任

地址:河南省新乡市金穗大道601号,新乡医学院医学检验学院,邮编 453003
邮箱(E-mail): immuneweb AT 126.com QQ号:308576883
FAX/TEL: 0373-3831203 (O),TEL:0373-3831887(lab)
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【研究课题】

1.成人T细胞白血病相关基因的研究 国家自然基金资助课题(NO.30670910)

2.在HTLV-1病毒感染的T细胞中Bcl3-NFkB-Tax蛋白关系的研究 国家自然基金资助课题 (N0.30972755)

3.在HTLV-1感染的T细胞中HMGB1、Tax和细胞自噬关系的研究 国家自然基金资助课题 (NO.81273241)

4.Bcl3对HTLV-1病毒感染细胞内NFkB通路和细胞自噬作用的分子机制 国家自然基金资助课题 (NO.81471559)

 

【研究内容】

1.最近几年主要从事HTLV-1病毒感染的T细胞内信号通路方面的研究,主要围绕Bcl3基因在病毒感染细胞中的生物学作用方面进行了探讨,研究显示:HTLV-1病毒Tax蛋白能促进T细胞内Bcl3的表达,并促进胞浆中的Bcl3向细胞核内聚集;Tax刺激的Bcl3的高表达,可以同时提高NFkB的活性,但过表达的Bcl3对NFkB活性起抑制作用;Bcl3可以促进细胞自噬。

The human T cell leukemia virus type 1 (HTLV-1) is a complex human retrovirus that causes an aggressive leukemia known as adult T cell leukemia (ATL). The HTLV-1-encoded oncoprotein Tax induces persistent activation of the nuclear factor-κB (NF-κB) pathway, which is perceived as the primary cause of ATL. Bcl-3, a member of the NF-κB inhibitor (IκB) family, is highly expressed in many HTLV-1-infected T cell lines and ATL cells. However, the role of Bcl-3 in Tax-induced NF-κB activation has not been fully elucidated. Here, we show that Tax induces Bcl-3 expression, which in turn negatively regulates the Tax-induced NF-κB activation. Interestingly, both Bcl-3 up-regulation and NF-κB inhibition promote the autophagy process in HTLV-1-infected cells. Consistent with this, over-expression of Bcl-3 also results in enhancement of rapamycin-, pifithrin-α- or starvation-induced autophagy in control cells. Together, these data demonstrate that Bcl-3 acts as a negative regulator of NF-κB activation and promotes autophagy in HTLV-1-infected cells.

2.探讨临床应用干扰素引起抑郁症的发生机制

3.探讨脂肪代谢和免疫的关系

 

【近期发表的论文】文章被引用频次

Wang J, Kang L, Song D, Liu L, Yang S, Ma L, Guo Z, Ding H, Wang H*, Yang B*.Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication. J Immunol. 2017 Aug 18. pii: ji1700111. doi: 10.4049/jimmunol.1700111. [Epub ahead of print](IF 4.8559)

Dong L.,Zhang Y,Yang L,Liu G, Ye J, Wang H*. Effects of a High-Fat Diet on Adipose Tissue CD8+ T Cells in Young vs. Adult Mice. Inflammation. 2017 Sep 2. doi: 10.1007/s10753-017-0635-0. [Epub ahead of print](IF. 2.95).

Huang Q, Niu Z, Han J, Liu X, Lv Z, Li H, Yuan L, Li X, Sun S, Wang H*, Huang X*. HTLV-1 Tax upregulates early growth response protein 1 through nuclear factor-κB signaling.Oncotarget. 2017 May 8. doi: 10.18632.(IF 5.168)

Zhao T, Jia H, Cheng Q, Xiao Y, Li M, Ren W, Li C, Feng Y, Feng Z, Wang H*, Zheng J*.Nifuroxazide prompts antitumor immune response of TCL-loaded DC in mice with orthotopically-implanted hepatocarcinoma. Oncol Rep.?2017 Jun;37(6):3405-3414.(IF 2.66)

Wang J, Yang S, Liu L, Wang H*, Yang B*. HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity.Virus Res2017 Mar 15;232:13-21(IF 2.628)

Yang H, Yu S, Wang W, Li X, Hou Y, Liu Z, Shi Y, Mu K, Niu G, Xu J, Wang H*, Zhu J*, Zhuang T*.SHARPIN Facilitates p53 Degradation in Breast Cancer Cells.Neoplasia. 2017 Feb;19(2):84-92.(IF 5.006)

Zhong J, Wang H, Yu J, Zhang J, Wang H*.Overexpression of Forkhead box L1 (FOXL1) inhibits the proliferation and invasion of breast cancer cells.Oncol Res. 2017 Jul 5;25(6):959-965.(IF 1.74)

Jia H, Zhao T, Ji Y, Jia X, Ren W, Li C, Li M, Xiao Y, Wang H*, Xu K*.Combined nifuroxazide and SAT05f therapy reduces graft-versus-host disease after experimental allogeneic bone marrow transplantation.Cell Death and Disease?(2016)?7, e2507; doi:10.1038/cddis.2016.399 (IF 5.378)

Feng H, Yu L, Zhang G, Liu G, Yang C, Wang H*, Song X*.Regulation of Autophagy-Related Protein and Cell Differentiation by High Mobility Group Box 1 Protein in Adipocytes. Mediators Inflamm. 2016;2016:1936386.(IF 3.418)

Zhu J, Zhuang T, Yang H, Li X, Liu H, Wang H*.Atypical ubiquitin ligase RNF31: the nuclear factor modulator in breast cancer progression.BMC Cancer. 2016 Jul 26;16(1):538. doi: 10.1186/s12885-016-2575-8 (IF 3.265)

Yu L, Liu G, Yang C, Song X, Wang H*Polyinosinic-polycytidylic acid inhibits the differentiation of mouse preadipocytes through pattern recognition receptor-mediated secretion of tumor necrosis factor-α.Immunol Cell Biol. 2016 Jul 5. doi: 10.1038/icb.2016.57. [Epub ahead of print](IF 4.47)

Zhang Y, Zhao Z, Ke B, Wan L, Wang H, Ye J. Induction of Posttranslational Modifications of Mitochondrial Proteins by ATP Contributes to Negative Regulation of Mitochondrial Function. 2016 Mar 1;11(3):e0150454(IF 3.057)

Guo J, Zhang W, Zhang L .....Wang H*. . Sci. Rep. 6, 17029; doi: 10.1038/srep17029 (2016)(IF 5.228)

Sun R, Zhang Y, Ma S, Qi H, Wang M, Duan J, Ma S, Zhu X, Li G, Wang H*.Down-regulation of mitogen-activated protein kinases and nuclear factor-κB signaling is involved in rapamycin suppression of TLR2-induced inflammatory response in monocytic THP-1 cells. Microbiol Immunol. 2015 Oct;59(10):614-22. doi: 10.1111/1348-0421.12321

Gao Z, Zhang J, Henagan TM, Lee JH, Wang H, Ye X, Ye J.p65 inactivation in adipocytes and macrophages attenuates adipose inflammatory response in lean but not in obese mice.Am J Physiol Endocrinol Metab.2015 Mar 15;308(6):E496-505(IF 3.825)

Wang H, Ye J.Regulation of energy balance by inflammation: Common theme in physiology and pathology.Rev Endocr Metab Disord. 2015 Mar;16(1):47-54.(IF 5.088)

Gao Z, Zhu M, Wu Y, Gao P, Qin Z, Wang H* Interferon-λ1 induces G1 phase cell cycle arrest and apoptosis in gastric carcinoma cells in vitro. Oncology Reports.2014 Jul;32(1):199-204. (IF 2.301)

Wang, J., Niu, Z., Shi, Y., Gao, C., Wang, X., Han, J., Li, J., Gao, Z., Zhu, X., Song, X., Qin, Z., Wang, H*., 2013. Bcl-3, induced by Tax and HTLV-1, inhibits NF-κB activation and promotes autophagy. Cellular Signaling. 2013,25(12): 2797–2804. (IF 4.304)

Wang, J., Li, J., Huang, Y., Song, X., Niu, Z., Gao, Z., Wang, H*., Bcl-3 suppresses Tax-induced NF-kappaB activation through p65 nuclear translocation blockage in HTLV-1-infected cells. Int J Oncol 2013.42, 269-276(IF 2.657)

Wang, J., Wang, X., Gao, C., Song, X., Niu, Z., Gao, Z., Qin, Z., Chang, J., Wang, H*, The pyrimidine analog FNC inhibits cell proliferation and viral protein synthesis in HTLV-1 infected cells. Molecular medicine reports.2013.7(5),1656-1660.

Wang, Y*., Wang, H*., Hegde, V., Dubuisson, O., Gao, Z., Dhurandhar, N., Ye, J., Interplay of pro-and anti-inflammatory cytokines to determine lipid accretion in adipocytes. International Journal of Obesity.2013,37(11):1490-1498 (IF 5.221)

Wu, H., Tao, N., Liu, X., Li, X., Tang, J., Ma, C., Xu, X., Shao, H., Hou, B., Wang, H*., Qin, Z., 2012. Polysaccharide from Lentinus edodes Inhibits the Immunosuppressive Function of Myeloid-Derived Suppressor Cells. PLoS One 7, e51751.

Zhang, G., Liu, X., Wang, C., Qu, L., Deng, J., Wang, H*., Qin, Z., 2013. Resolution of PMA-Induced Skin Inflammation Involves Interaction of IFN-and ALOX15. Mediators of Inflammation . dx.doi.org/10.1155/2013/930124

 


 

 

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